Primary Systemic Amyloidosis

A case of primary systemic amyloidosis with nail dystrophy

We hereby report a 79-year-old Iranian man presenting with nail dystrophy and subsequent development of purpuric and ecchymotic plaques, hemorrhagic bullae, and infiltrated papules on the head, neck and trunk. Histological examination of the gingiva, bone marrow aspiration, and biopsy confirmed the diagnosis of primary systemic amyloidosis. In this case, nail dystrophy was the presenting sign o...

گزارش یک مورد آمیلوییدوز سیستمیک در حنجره

    Introduction: Amyloidosis is an idiopathic disorder characterized by amyloid deposition leading to tissue damage and disease. Laryngeal amyloidosis is usually a localized phenomenon that is rarely accompanied by systemic involvement. Hoarseness is its most common symptom and the clinical findings in laryngoscopy are variable, nonspecific and difficult to be distinguished from other laryngea...

Primary systemic amyloidosis and the gastrointestinal tract.

Clinical manifestations of primary amyloidosis can be subtle, particularly when the gastrointestinal tract is involved. We present two cases that illustrate the diversity of such involvement and the subsequent problems with diagnosis. Gastrointestinal effects of primary systemic amyloidosis are reviewed and clinical pointers towards diagnosis are discussed. In particular these cases illustrate ...

Amyloidosis in the Skin

Amyloidosis is induced by deposition of amyloid proteins in various organs. Both systemic and localized type amyloidosis present with a variety of skin manifestations. Based on biochemical and immunological aspects, amyloid proteins are subdivided into several subtypes from different origins. Amyloid fibrils in primary and multiple myelomaassociated systemic amyloidosis are composed of immunogl...

Primary systemic amyloidosis associated with multiple myeloma: a case report and review of the literature.

Amyloidosis is a broad and complex class of diseases that comprises several etiologies, many manifestations, and a diversity of outcomes. We discuss a patient with primary systemic amyloidosis associated with multiple myeloma that illustrates many of the typical and atypical features of the disease process. Despite more in-depth assessment and accurate classification, survival for patients with...

Amyloidosis - Pathogenesis | Systemic amyloidosis | Pharmacybook